BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)

Conditions:   Pulmonary Tuberculoses;   Other Specified Pulmonary Tuberculosis Interventions:   Drug: BTZ-043;   Drug: Rifafour e-275®;   Drug: Probe Drug Cocktail;   Drug: Dolutegravir 50mg Tab Sponsors:   Michael Hoelscher;   European and Developing Countries Clinical Trials Partnership (EDCTP);   Radboud University;   German Federal Ministry of Education and Research Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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ConclusionsTB can have varied presentation and therefore it is essential to keep tubercular infection in differential diagnosis while working up for any infective pathology. Conservative treatment produces good results in vast majority of cases. Surgery is reserved for select indications.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
A deep-learning algorithm that analyzed chest x-rays was able to predict pulmonary...Read more on AuntMinnie.comRelated Reading: Deep-learning algorithm bolsters lung cancer detection AI may help improve sensitivity of ED chest x-ray reads AI model could speed up pneumonia diagnosis in ED AI detects pulmonary nodules on chest x-rays Are studies on AI for tuberculosis really valid?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 21 January 2020Source: Microbial PathogenesisAuthor(s): Guoying Deng, Na Ji, Xiaoxia Shi, Wenli Zhang, Yuanhua Qin, Shanshan Sha, Shufeng Yang, Yufang MaAbstractMycobacterium tuberculosis is capable of escaping the clearance of immune system mainly due to its complex constituents of cell wall. Certain studies show that glycoproteins are involved in immune evasion and act as virulence factors. Peptidoglycan deacetylase Rv1096 is a member of mannosylated proteins. Previously, we reported Rv1096 protein contributed to the resistance of Mycobacterium smegmatis (M. smegmatis) to lysozyme, but ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Condition:   Tuberculosis Infection Intervention:   Other: TB infection-screening benefiting group Sponsors:   Hospital Mutua de Terrassa;   Public Health Agency of Barcelona;   Hospital Vall d'Hebron;   Hospital Sant Joan de Deu;   Institut Català de la Salut;   Hospital Universitari Sant Joan de Reus;   Hospital de Tortosa Verge de la Cinta Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pulmonary Tuberculosis;   Extra Pulmonary Tuberculosis Intervention:   Genetic: immunogenetics Sponsor:   Assistance Publique - Hôpitaux de Paris Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study evaluated the HIV/TB co-infection rate among HIV-1 infected individuals in old Cross River State, Nigeria. A total of 417 HIV-infected individuals participated in this study, 241 (57.8%) from Calabar, Cross River State, Nigeria and 176 (42.2%) from Uyo, Akwa-Ibom State, Nigeria. The age range of the 417 HIV-1 positive individuals who participated in the study was 4-72 years with an average age of 39.1 years. Plasma samples were analyzed for HIV and TB using fourth-generation Enzyme-Linked immunosorbent Assay. The CD4 count was enumerated using the Partec CyFlow® Counter. Plasma viral loads (PVL) we...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
[East African] The Global Fund, the body that finances the world's HIV, tuberculosis (TB) and malaria programmes, has given Kenya Ksh42 billion ($420 million) to cover the intervening years to 2024.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 20 January 2020Source: International Journal of PaleopathologyAuthor(s): Elizabeth A. Nelson, Jane E. Buikstra, Alexander Herbig, Tiffiny A. Tung, Kirsten I. BosAbstractAndean paleopathological research has significantly enhanced knowledge about the geographical distribution and evolution of tuberculosis (TB) in pre-Columbian South America. In this paper, we review the history and progress of research on ancient tuberculosis (TB) in the Andean region, focusing on the strengths and limitations of current approaches for the molecular detection of ancient pathogens, with special attention to...
Source: International Journal of Paleopathology - Category: Pathology Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Background: Understanding macrophage behavior is key to decipher Mycobacterium tuberculosis (Mtb) pathogenesis. We studied the phenotype and ability of human monocyte-derived cells polarized with active vitamin D [1,25(OH)2D3] to control intracellular Mtb infection compared with polarization of conventional subsets, classical M1 or alternative M2.Methods: Human blood-derived monocytes were treated with active vitamin D or different cytokines to obtain 1,25(OH)2D3-polarized as well as M1- and M2-like cells or fully polarized M1 and M2 subsets. We used an in vitro macrophage Mtb infection model to assess both phenotype and f...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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