Effects of Statins on Relative Risk of Fractures for Older Adults: An Updated Systematic Review With Meta-Analysis

Basic and translational studies have found statin treatment may have beneficial effects on bone metabolism; however, whether statins reduce the risk of fractures in older adults is still in debate. Therefore, we aimed to summarize the up-to-date evidence on risk of fracture among older individuals with statin use.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Original Study Source Type: research

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This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Sophie Lau, Naomi Stanhope, John Griffin, Eleri Hughes, David Middleton NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
First study of its kind to show that although low doses of statins appear protective of bone health, high doses may increase risk for osteoporosis.Medscape Medical News
Source: Medscape Radiology Headlines - Category: Radiology Tags: Diabetes & Endocrinology News Source Type: news
Conclusions: The current meta-analysis found that the risk of GERD was numerically lower among statin users although the pooled result did not reach statistical significance. Therefore, more studies are still needed to further clarify this potential benefit of statins.
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Jenq-Lin Yang, Yun-Ru Yang, Shang-Der ChenAbstractStroke is the major cause of adult disability and the second or third leading cause of death in developed countries. The treatment options for stroke (thrombolysis or thrombectomy) are restricted to a small subset of patients with acute ischemic stroke because of the limited time for an efficacious response and the strict criteria applied to minimize the risk of cerebral hemorrhage. Attempts to develop new treatments, such as neuroprotectants, for acute ischemic stroke have been costly and tim...
Source: Life Sciences - Category: Biology Source Type: research
Lipoprotein(a) [Lp(a)] has been considered as a causal risk factor for cardiovascular disease (CVD) in the general population and levels vary in different ethnicities. However, no systemic analysis is currently available regarding the relation of plasma Lp(a) levels to cardiovascular events (CVEs) in Chinese patients with heterozygous familial hypercholesterolemia (HeFH).
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
ConclusionBased on our results we can assume that atorvastatin and rutin had possitive effect on spatial memory and vessel reactivity. Atorvastatin optimized lipid profile of blood serum.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
ConclusionPMRP and TSG improved lipid accumulation and inflammation, and regulated the intestinal microbial imbalance in ApoE−/- mice. TSG exerted a preventive effect in the development and progression of AS.Graphical abstractInflammation Inhibition and Gut Microbiota Regulation of TSG on in ApoE−/- Mice, Fengjiao Li, Ting Zhang, Yanran He et al. JEP_112232.
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Maximal doses of potent statins are the basement of treatment of familial hypercholesterolemia (FH). Little is known about the use of different statin regimens in FH.
Source: Journal of Clinical Lipidology - Category: Lipidology Authors: Tags: Original Research Source Type: research
PMID: 31600131 [PubMed - in process]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
Authors: Lee N, Maeda K, Fukizawa S, Ieiri I, Tomaru A, Akao H, Takeda K, Iwadare M, Niwa O, Masauji T, Yamane N, Kajinami K, Kusuhara H, Sugiyama Y Abstract The present study investigated whether the clinical pharmacokinetics of atorvastatin can be predicted from the results of microdosing study in Japanese patients with hypercholesterolemia whose SLCO1B1 and ABCG2 polymorphisms were analyzed. Forty seven statin-naive patients clinically indicated to LDL cholesterol-lowering therapy with atorvastatin were enrolled in a two-period crossover study. Microdose (100 μg) of atorvastatin was orally administered f...
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
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