New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes

Conclusions We introduce new methods for the efficient and informative characterization of siRNA polyplexes with special attention to stability. Comparing FRET-labeled siRNA in different polyplexes associates successful knockdown with intermediate siRNA stability in various steps from formulation to intracellular persistence.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research