Case of autoimmune neutropenia with severe marginal periodontitis

Publication date: Available online 3 August 2019Source: Pediatric Dental JournalAuthor(s): Setsuyo Morimoto, Keiko Hirano, Keiko Tabata, Haruka Asaumi, Yuko Morikawa, Yuki Matsumi, Shuhei Naka, Michiyo Matsumoto-NakanoAbstractEarly onset periodontitis is rarely seen in infants, though often leads to an acute and serious clinical course when encountered in such patients. Autoimmune neutropenia presents systemic and dental symptoms, as depressed resistance to bacterial infection is caused by a disorder that reduces the number of neutrophils. This disease can result in not only gingival inflammation but also destruction of periodontal tissues, such as attachment loss, alveolar bone absorption, and early tooth loss in primary as well as mixed dentition. Here, we report treatment of a child with marginal periodontitis from the age of 3 years–7 years 9 months. No systemic manifestations were noted until 3 years of age, thus the patient had never received a detailed examination or medication related to the disease. Following examinations at our department, we referred the patient to a pediatrician at our university hospital for possible systemic disease, who made a diagnosis of autoimmune neutropenia. Although administration of antibiotics and professional dental care were continued, neutrophil count was not increased and progressive periodontal destruction was observed. Extraction of teeth with poor prognosis was performed and a prosthetic strategy for the missing teeth developed...

Source: Pediatric Dental Journal - August 4, 2019 Category: Dentistry Source Type: research