Reply to: “Comment on ‘Magnesium supplementation in the treatment of pseudoxanthoma elasticum: Is magnesium oxide the best choice?'”

To the Editor: We thank Dr Omarjee for his thought-provoking  letter.1 The reason that we used magnesium oxide in our studies was because that form of magnesium was indeed the form studied by Kupetsky-Rincon et al to reduce carotid intima-media thickness in a mouse model of pseudoxanthoma elasticum (PXE).2 We are, however, intrigued by Dr Omarjee's points a bout magnesium citrate and agree that clinical trials with alternative forms of magnesium might be worthwhile. There are, however, newer candidates that interfere with calcification that are likely to be studied sooner, and because of PXE's rarity, multiple studies of different compounds will be cha llenging.

Source: Journal of the American Academy of Dermatology - July 3, 2019 Category: Dermatology Authors: Mark Lebwohl, Sharon Rose, Wayne Fuchs, Sharon F. Terry Tags: JAAD Online Source Type: research