In vitro Activation Prior to Transplantation of Human Ovarian Tissue: Is It Truly Effective?

CONCLUSION: We were unable to demonstrate any significant benefits of cutting ovarian tissue into small cubes and applying IVA with Akt stimulators. The association of vitrification and transplantation was actually found to be the most deleterious combination with respect to the follicle reserve, and even worse when culture with Akt stimulators was performed.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research