Molecules, Vol. 24, Pages 2807: Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids

Molecules, Vol. 24, Pages 2807: Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids
Molecules doi: 10.3390/molecules24152807
Authors:
Md. Khalid Anwer
Mohammad Muqtader
Muzaffar Iqbal
Raisuddin Ali
Bjad K. Almutairy
Abdullah Alshetaili
Saad M. Alshahrani
Mohammed F. Aldawsari
Ahmed Alalaiwe
Faiyaz Shakeel

Estimating the solubility and solution thermodynamics parameters of aliskiren hemifumarate (AHF) in three different room temperature ionic liquids (RTILs), Transcutol-HP (THP) and water are interesting as there is no solubility data available in the literature. In the current study, the solubility and solution thermodynamics of AHF in three different RTILs, THP and water at the temperature range from 298.2 to 318.2 K under air pressure 0.1 MP were evaluated. The solid phase evaluation by Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (PXRD) indicated no conversion of AHF into polymorph. The mole fraction solubility of AHF was found to be highest in 1-hexyl-3-methylimidazolium hexafluorophosphate (HMMHFP) ionic liquid (7.46 × 10−2) at 318.2 K. The obtained solubility values of AHF was regressed by the Apelblat and van’t Hoff models with overall root mean square deviations (RMSD) of 0.62% and 1.42%, respectively. The ideal solubility of AHF was higher compared to experimental solubility values at d...

Source: Molecules - July 31, 2019 Category: Chemistry Authors: Md. Khalid Anwer Mohammad Muqtader Muzaffar Iqbal Raisuddin Ali Bjad K. Almutairy Abdullah Alshetaili Saad M. Alshahrani Mohammed F. Aldawsari Ahmed Alalaiwe Faiyaz Shakeel Tags: Article Source Type: research