Bone allografts combined with adipose-derived stem cells in an optimized cell/volume ratio showed enhanced osteogenesis and angiogenesis in a murine femur defect model

In this study, we systemically optimized cell/volume ratio of two promising components of tissue engineering: hASCs and human bone allografts. These findings may serve as a basis for future translational studies.Key messagesBone tissue engineering.Mesenchymal stem cells derived from human adipose tissue (hASCs).Optimal cell/volume ratio of cell-seeded scaffolds.Increased osteogenesis and angiogenesis in vivo.

http://link.springer.com/10.1007/s00109-019-01822-9

Source: Journal of Molecular Medicine - July 30, 2019 Category: Molecular Biology Source Type: research