Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes

K channel interacting protein 2 (KChIP2), initially cloned as Kv4 channel modulator, is a multi-tasking protein. In addition to modulating several cardiac ion channels at the plasma membrane, it can also modulate microRNA transcription inside nuclei, and interact with presenilins to modulate Ca release through RyR2 in the cytoplasm. However, the mechanism regulating its subcellular distribution is not clear.

Source: Journal of Molecular and Cellular Cardiology - July 26, 2019 Category: Cytology Authors: Akshay Murthy, Samuel Workman, Min Jiang, Junping Hu, Ismat Sifa, Tytus Bernas, Wanchun Tang, Isabelle Deschenes, Gea-Ny Tseng Source Type: research