Tityus serrulatus Scorpion Venom Induces Apoptosis in Cervical Cancer Cell Lines.

In this study, we investigated the effect of Tityus serrulatus scorpion venom (TsV) on CC lines. There are very few studies exploring venom of scorpions, and, to our knowledge, no study has been conducted using the venom of the scorpion TsV for treatment of cervical cancer lines. After challenge with TsV, the MTT assay demonstrated cytotoxic effect on HeLa line. Similarly, the cell death process in HeLa analyzed by flow cytometry suggests death via caspase, since the pan-caspase inhibitor z-VAD-fmk significantly reduced the apoptotic response to the treatment. These results suggest that venom of TsV can be a potential source for the isolation of effective antiproliferative and apoptotic molecules in the treatment of CC. PMID: 31341494 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/31341494?dopt=Abstract

Source: Evidence-based Complementary and Alternative Medicine - July 27, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research