Roles and mechanisms of SUMOylation on key proteins in myocardial ischemia/reperfusion injury

Myocardial ischemia/reperfusion (MI/R) injury has a great influence on the prognosis of patients with acute coronary occlusion. The underlying mechanisms of MI/R injury are complex. While the incidence of MI/R injury is increasing every year, the existing therapies are not satisfactory. Recently, small ubiquitin-related modifier (SUMO), which is a post-translational modification and involved in many cell processes, was found to play remarkable roles in MI/R injury. Several proteins that can be SUMOylated were found to interfere with different mechanisms of MI/R injury.

Source: Journal of Molecular and Cellular Cardiology - July 21, 2019 Category: Cytology Authors: Jingwen Chen, Yuanyuan Luo, Shuai Wang, Hong Zhu, Dongye Li Tags: Review article Source Type: research