Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation.

CONCLUSIONS: This study demonstrated that col.(V) is an rapidly recognized by B cells and has specific transcriptional signature. In lung transplants recipients the rapid seroconversion to anti-col(V) Ab is linked to increased risk of grade 3 PGD.
PMID: 31325493 [PubMed - as supplied by publisher]

Source: Transplant Immunology - July 16, 2019 Category: Transplant Surgery Authors: Zaffiri L, Shah RJ, Stearman RS, Rothhaar K, Emtiazjoo AM, Yoshimoto M, Fisher AJ, Mickler EA, Gartenhaus MD, Cohort LTOG, Diamond JM, Geraci MW, Christie JD, Wilkes DS Tags: Transpl Immunol Source Type: research