Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles.
Identification of clinically relevant subgroups of COPD based on airway and circulating autoantibody profiles. Mol Med Rep. 2019 Jul 12;: Authors: Liang Z, Long F, Wang F, Yang Y, Xiao J, Deng K, Gu W, Zhou L, Xie J, Jian W, Chen X, Jiang M, Zheng J, Peng T, Chen R Abstract Autoimmunity may serve a role in the pathological features of a subgroup of patients with chronic obstructive pulmonary disease (COPD); however, in immunological subgroups of COPD patients, the interrelationships between airway and circulating autoantibody responses, and clinical parameters, remain unclear. The present study was undertaken to evaluate these interrelationships in various immunological subgroups of COPD patients. Sputum supernatant and serum obtained from 102 patients with stable COPD were assayed for the presence of immunoglobulin G antibodies against ten autoantigens via Luminex multiplex technology. Hierarchical clustering based on principal components was performed on autoantibody profiles to classify patients into clusters. Network‑based and module analyses were conducted to explore interrelationships among autoantibodies and clinical variables in each cluster. Topological characteristics were compared between clusters. Unsupervised clustering identified four clusters: No significant differences in the majority of clinical characteristics were observed among clusters. In cluster 1, retrospective exacerbation was only positively associated with COPD assessment...
People with HIV are greater risk of developing illnesses that are normally associated with age, such as increased incidence of heart disease, chronic obstructive pulmonary disease and bone fractures.
To assess the budget impact of restricting inappropriate inhaled corticosteroids (ICS) use according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD)-guidelines indication for ICS use in the chronic obstructive pulmonary disease (COPD)-population, taking The Netherlands as a reference case.
Conclusions: The ACO cohort with statin use exhibited the lower risk of hepatic, renal, and heart failure than any other cohort, regardless of age, sex, comorbidities, or ICS or OS use. Regarding the combined use of statins and ICS, the risks of hepatic failure were lower. For the combined use of statins and OS, the hepatic, renal and heart failure were less frequent.
The objective of this study was to compare the 30-day outcomes for these two treatment groups for multilevel cervical pathology. Methods. Patients who underwent cervical laminoplasty or posterior laminectomy and fusion were identified in National Surgical Quality Improvement Program (NSQIP) based on Current Procedural Terminology (CPT) code: laminoplasty 63,050 and 63,051, posterior cervical laminectomy 63,015 and 63,045, and instrumentation 22,842. Propensity-adjusted multivariate regressions assessed differences in postoperative length of stay, adverse events, discharge disposition, and readmission. Results. Three ...
This study demonstrated that US adults with COPD have a much higher prevalence of arthritis than those without, even when accounting for sociodemographic factors and other variables.Preventing Chronic Disease