Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Vu Kim Thu, Nguyen Xuan Bach, Luu The Anh, Do Thi Trang, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, SeonJu Park, Yohan Seo, Wan Namkung, Seung Hyun KimAbstractFive new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC50 value of 22.0 ± 1.7 μM without any cytotoxicity.Graphical abstract

Source: Phytochemistry Letters - July 20, 2019 Category: Chemistry Source Type: research