Electroacupuncture Intensity and Chronic Pain in Knee OA Electroacupuncture Intensity and Chronic Pain in Knee OA

High intensity electroacupuncture provided more beneficial effects on osteoarthritis pain than lower intensity, according to a new study.Arthritis Research &Therapy
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

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In conclusion, with study of the frailty syndrome still in its infancy, frailty analysis remains a major challenge. It is a challenge that needs to be overcome in order to shed light on the multiple mechanisms involved in the pathogenesis of this syndrome. Although several mechanisms contribute to frailty, immune system alteration seems to play a central role: this syndrome is characterized by increased levels of pro-inflammatory markers and the resulting pro-inflammatory status can have negative effects on various organs. Future studies should aim to better clarify the immune system alteration in frailty, and seek to esta...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsMore than half of Medicaid beneficiaries receiving an opioid for pain management do so for orthopedic- and dental-related reasons, with emergency department providers more likely to prescribe opioids. Modifications to the guidelines addressing temporary acute pain management practices with opioids would be likely to benefit emergency department providers the most.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
In this study, UBX0101 was well-tolerated. Improvement in several clinical outcomes, including pain and function, as well as modulation of certain senescence-associated secretory phenotype (SASP) factors and disease-related biomarkers was observed after a single dose of UBX0101. UNITY plans to initiate a Phase 2 study of UBX0101 in patients with painful, moderate-to-severe OA of the knee. The study is expected to enroll approximately 180 patients with initiation expected in the fourth quarter of 2019 and initial 12-week results expected in the second half of 2020. This will be a randomized, double-blind, placebo-con...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conditions:   Hip Dysplasia;   Hip Pain Chronic;   Hip Osteoarthritis;   Hip Arthritis;   Psychosocial Problem Interventions:   Device: Cell Phone Based Cognitive Based Therapy (Pacifica App);   Other: Control Sponsor:   Michael C Willey Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Knee pain due to arthritis or injury is the second most common cause of chronic pain in the United States. Osteoarthritis affects more than 30 million adults in the United States. And the rate of anterior cruciate ligament (ACL) tears among children and teens has been increasing about 2.3% per year for the past two decades, according to a new study. The specific cause of a patient’s knee pain has always been difficult to determine because diagnostic tools such as x-ray or MRI only image the joint in a static standing or lying down position, not in motion when the patient is feeling pain. â€...
Source: MDDI - Category: Medical Devices Authors: Tags: Orthopedics Source Type: news
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ObjectiveTo assess the efficacy and safety of high ‐purity synthetic trans‐capsaicin (CNTX‐4975) in patients with chronic moderate‐to‐severe osteoarthritis (OA)–associated knee pain.MethodsIn this phase II multicenter double ‐blind study, patients ages 45–80 years who had stable knee OA were randomized in a 2:1:2 ratio to receive a single intraarticular injection of placebo, CNTX‐4975 0.5 mg, or CNTX‐4975 1.0 mg. The primary efficacy end point was area under the curve (AUC) for change from baseline in daily West ern Ontario and McMaster Universities Osteoarthritis Index pain with walking score (...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
This study will be a randomized, double-blind, parallel positive controlled, multi-center clinical trial, a non-inferiority trial design was adopted. A total of 2000 participants older than 40  years, with KOA, will be randomly allocated into an experimental group (n = 1500) and a control group (n = 500). All participants will receive a conventional conservative treatment lasting for 14 days as two courses, once daily. Tong-luo Qu-tong plaster will be administered externally to participants in the experimental group, while the control group will receive a Qi-zheng Xiao-tong plaster...
Source: Trials - Category: Research Source Type: clinical trials
Conditions:   Knee Osteoarthritis;   Knee Pain Chronic;   Knee Arthritis Intervention:   Device: Active NMES Sponsor:   CyMedica Orthopedics, Inc Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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