High-density Lipoprotein-based Therapy Reduces the Hemorrhagic Complications Associated With Tissue Plasminogen Activator Treatment in Experimental Stroke [Clinical Sciences]

Conclusions— HDL injection decreased tPA-induced hemorrhagic transformation in rat models of MCAO. Both in vivo and in vitro results support the vasculoprotective action of HDLs on BBB under ischemic conditions.

http://stroke.ahajournals.org/cgi/content/short/44/3/699?rss=1

Source: Stroke - February 25, 2013 Category: Neurology Authors: Lapergue, B., Dang, B. Q., Desilles, J.-P., Ortiz-Munoz, G., Delbosc, S., Loyau, S., Louedec, L., Couraud, P.-O., Mazighi, M., Michel, J.-B., Meilhac, O., Amarenco, P. Tags: Lipids, Animal models of human disease, Acute Cerebral Infarction, Emergency treatment of Stroke, Neuroprotectors, Thrombolysis, Endothelium/vascular type/nitric oxide Clinical Sciences Source Type: research