Associations between bone impact microindentation and clinical risk factors for fracture.

This study investigated associations between BMSi and clinical risk factors for fracture in men. BMSi was measured using the OsteoProbe in 357 men (ages 33-96yr) from the Geelong Osteoporosis Study. Risk factors included age, weight, height, body mass index (BMI), femoral neck BMD, parental hip fracture, prior fracture, type 2 diabetes mellitus (T2DM), secondary osteoporosis, smoking, alcohol consumption, sedentary lifestyle, medications, diseases and low serum vitamin D levels. BMSi was negatively associated with age (r = -0.131, p=0.014), weight (r = -0.109, p=0.040) and BMI (r = -0.083, p=0.001); no correlations were detected with BMD (r = 0.000, p=0.998) or height (r = 0.087, p=0.10). Mean BMSi values for men with and without prior fracture were 80.2±6.9 vs 82.8±6.1 (p=0.024); parental hip fracture 80.1±6.1 vs 82.8±6.9 (p=0.029); T2DM 80.3 ± 8.5 vs 82.9 ± 6.6 (p=0.059). BMSi did not differ in the presence vs absence of other risk factors. In multivariable models, mean(±SD) BMSi remained associated with prior fracture and parental hip fracture after adjusting for age and BMI: prior fracture (80.5±1.1 vs 82.8±0.4, p=0.044); parental fracture (79.9±1.2 vs 82.9±0.4, p=0.015). No other confounders were identified. We conclude that in men, BMSi discriminates prior fracture and parental hip fracture, which are both known to increase the risk for incident fracture. These findings suggest that IMI may be useful for identifying men who have an increased risk for fracture...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research