Nipah Virus Infection.

Nipah Virus Infection. J Assoc Physicians India. 2018 Dec;66(12):58-60 Authors: Av R, Sadanandan S, Thulaseedharan NK, Kg SK, Pallivalappil B, As AK Abstract Nipah Virus Infection is an emerging zoonotic infection which presents with acute encephalitis and respiratory distress syndrome. It is associated with high mortality and classified as Biosafety level 4 organisms in view of its features which make it a potential agent for Bioterrorism. Experience with broad spectrum antiviral agent Ribavirin is promising in reducing the mortality and morbidity. PMID: 31313551 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research

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Nipah virus is an emerging pathogenic paramyxovirus responsible for sporadic and isolated outbreaks of severe respiratory and neurologic disease in Southern Asia. As a zoonotic virus, disease can manifest in both animals and human with indigenous fruit bats acting as natural reservoirs of the virus. The effects of viral infection vary from acute respiratory distress to fatal encephalitis. There are currently no approved therapeutics or vaccines against the virus, and growing concerns that this highly pathogenic infection has the potential to cause larger epidemics capable of inflicting significant mortality burden.Like the...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
Authors: Singh RK, Dhama K, Chakraborty S, Tiwari R, Natesan S, Khandia R, Munjal A, Vora KS, Latheef SK, Karthik K, Singh Malik Y, Singh R, Chaicumpa W, Mourya DT Abstract Nipah (Nee-pa) viral disease is a zoonotic infection caused by Nipah virus (NiV), a paramyxovirus belonging to the genus Henipavirus of the family Paramyxoviridae. It is a biosafety level-4 pathogen, which is transmitted by specific types of fruit bats, mainly Pteropus spp. which are natural reservoir host. The disease was reported for the first time from the Kampung Sungai Nipah village of Malaysia in 1998. Human-to-human transmission also occu...
Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research
Publication date: Available online 26 February 2019Source: Microbes and InfectionAuthor(s): Nazia Thakur, Dalan BaileyAbstractNipah virus is an emerging zoonotic paramyxovirus that causes severe and often fatal respiratory and neurological disease in humans. The virus was first discovered after an outbreak of encephalitis in pig farmers in Malaysia and Singapore with subsequent outbreaks in Bangladesh or India occurring almost annually. Due to the highly pathogenic nature of NiV, its pandemic potential, and the lack of licensed vaccines or therapeutics, there is a requirement for research and development into highly sensit...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Purpose: Nipah virus (NiV), a paramyxovirus, causes febrile encephalitis and severe respiratory disease in humans and animals. Nipah virus outbreaks have been reported from Malaysia, Bangladesh, India and Singapore. The case positive in humans have been attributed to zoonotic transmission from pigs and bats, human-to-human transmission, and eating fruits or juices contaminated with bat secretions. At present no vaccines or drugs are available for those infected with NiV. Fruit bats of family Pteropodidae have been identified as the reservoir for NiV.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 20.066 Source Type: research
Publication date: Available online 17 June 2017 Source:Antiviral Research Author(s): Anne L. Hotard, Biao He, Stuart T. Nichol, Christina F. Spiropoulou, Michael K. Lo The henipaviruses Nipah virus and Hendra virus are highly pathogenic zoonotic paramyxoviruses which have caused fatal outbreaks of encephalitis and respiratory disease in humans. Despite the availability of a licensed equine Hendra virus vaccine and a neutralizing monoclonal antibody shown to be efficacious against henipavirus infections in non-human primates, there remains no approved therapeutics or vaccines for human use. To explore the possibility of de...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract The henipaviruses Nipah virus and Hendra virus are highly pathogenic zoonotic paramyxoviruses which have caused fatal outbreaks of encephalitis and respiratory disease in humans. Despite the availability of a licensed equine Hendra virus vaccine and a neutralizing monoclonal antibody shown to be efficacious against henipavirus infections in non-human primates, there remains no approved therapeutics or vaccines for human use. To explore the possibility of developing small-molecule nucleoside inhibitors against henipaviruses, we evaluated the antiviral activity of 4'-azidocytidine (R1479), a drug previously...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
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Source: FEBS Letters - Category: Biochemistry Authors: Tags: Review Source Type: research
Summary Many wild swine populations in different parts of the World have experienced an unprecedented demographic explosion that may result in increased exposure of humans to wild swine zoonotic pathogens. Interactions between humans and wild swine leading to pathogen transmission could come from different ways, being hunters and game professionals the most exposed to acquiring infections from wild swine. However, increasing human settlements in semi‐natural areas, outdoor activities, socio‐economic changes and food habits may increase the rate of exposure to wild swine zoonotic pathogens and to potentially emerging pa...
Source: Transboundary and Emerging Diseases - Category: Veterinary Research Authors: Tags: Review Article Source Type: research
by Peter J. Hotez, Maria Elena Bottazzi, Ulrich Strych, Li-Yen Chang, Yvonne A. L. Lim, Maureen M. Goodenow, Sazaly AbuBakar The ten member states of the Association of Southeast Asian Nations (ASEAN) constitute an economic powerhouse, yet these countries also harbor a mostly hidden burden of poverty and neglected tropical diseases (NTDs). Almost 200 million people live in extreme poverty in ASEAN countries, mostly in the low or lower middle-income countries of Indonesia, the Philippines, Myanmar, Viet Nam, and Cambodia, and many of them are affected by at least one NTD. However, NTDs are prevalent even among upper middle...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Although a globe box-type highly contained laboratory with the internationally-recognized biosafety level-4 standards has been constructed in the Murayama Annex, the National Institute of Infectious Diseases, Tokyo, Japan (NIID) in 1981, the laboratory has never been operated as BSL-4 laboratory since its construction. Furthermore, there are no other BSL-4 laboratories in operation in Japan. The evidence indicates that infectious BSL-4 pathogens such as Ebola and Marburg viruses cannot be manipulated in Japan, making it impossible to study the BSL-4 pathogens using the infectious viruses. A large-scale ou...
Source: Uirusu. Journal of Virology - Category: Virology Authors: Tags: Uirusu Source Type: research
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