Application of Blood Oxygenation Level–Dependent Magnetic Resonance Imaging and Intravoxel Incoherent Motion to Assess Bilateral Renal Pathophysiological Processes Induced by Iodixanol Renal Artery First-Pass in Rabbit Model

Background Noninvasive blood oxygen level–dependent imaging and intravoxel incoherent motion sequences were used to assess bilateral renal oxygenation, hemodynamics, and proton diffusion in iodixanol renal artery first-pass in rabbit model. Methods Forty-two rabbits were divided into 2 groups. Saline and iodixanol (1 g iodine/kg, left renal artery) were administered. Magnetic resonance imaging scans were acquired longitudinally at 24 hours prior to and 1, 24, 48, and 72 hours after administration to assess apparent diffusion coefficient, pure molecular diffusion (D), perfusion-related diffusion (D*), volume fraction (f), and relative spin-spin relaxation rate (R2*) values, respectively. The experiment evaluated serum creatinine, histological, and hypoxia-inducible factor 1α immunoexpression. Results During 1 to 48 hours, the values of D, f, and D* significantly decreased (P
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: Abdominal Imaging Source Type: research