Real-world Study of Anti-TNFa Treatment Regimes of Hyrimoz or Zessly in Patients With Crohn ´s Disease
Condition: Crohn´s Disease Intervention: Sponsor: Novartis Pharmaceuticals Recruiting
Authors: Kim S, Kang Y, Park S, Koh H, Kim S Abstract BACKGROUND: It has been known that vitamin D level (serum 25[OH]D) has correlation with inflammatory bowel disease (IBD). The purpose of this study is to investigate changes of serum 25[OH]D in pediatric IBD patients according to the disease activity. METHODS: A total of 96 children and adolescent with IBD were enrolled in this retrospective study. Serologic inflammatory markers and clinical disease activity scores of the patients were collected, and their correlations with serum 25[OH]D were analyzed. Seasonal variations of serum 25[OH]D were also investiga...
Condition: Crohn Disease Intervention: Other: Soy based diet Sponsors: Case Western Reserve University; University of California, Davis; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University Hospitals Cleveland Medical Center Not yet recruiting
The Crohn’s-like lymphoid reaction (CLR) to colorectal cancer (CRC), a CRC-specific ectopic lymphoid reaction, is thought to play an important role in the host response to CRC. CLR is characterized by peritumoral lymphocytic aggregates that are found at the advancing edge of the tumor. Spatial and molecular characterization of CLR within the tumor microenvironment (TME) have uncovered a spectrum of peritumoral lymphoid aggregates with varying levels of organization and maturation. In early stages of CLR development, CD4+ T-cells cluster predominantly with mature antigen presenting dendritic cells. As CLR matures, inc...
We report a case of a 46-year-old Chinese male who presented with six months history of abdominal pain, weight loss and rectal bleeding. Diagnostic colonoscopy revealed multiple aphthous ulcers within the ileo-caecal region and distal transverse colon, separated by normal mucosa, mimicking skip lesions of Crohn's colitis. Computer topography (CT) scan of the abdomen showed multiple circumferential thickenings involving predominantly the right colon. A clinical diagnosis of colonic Crohn's disease with possible perforation was made. An extended right hemicolectomy was performed due to uncontrolled rectal bleeding. Histopath...
Introduction: Inflammatory bowel disease (IBD) and hidradenitis suppurativa (HS) are both chronic inflammatory diseases with a big impact in the quality of life of the patients. It has been described a higher prevalence of HS among patients diagnosed with IBD, especially Crohn disease. Some drugs used in HS, such as antibiotics, can be harmful for IBD patients and they may trigger flare ups. Adalimumab is anti-TNF drug which is approved for the treatment of both diseases, being the doses similar in both disorders.
Background: The pathogenesis of psoriasis may involve a breakdown of immune tolerance to cutaneous microorganisms. Guttate and chronic plaque psoriasis are associated with Streptococcus pyogenes colonization. In addition, Crohn disease and periodontitis, two diseases due to immune activation in response to microbiota, have been reported at a higher incidence in patients with psoriasis.
Background: Squamous cell carcinoma (SCC), however rare in the anogenital skin, is often locally aggressive. Development of anogenital SCC is related to several other dermatologic and related conditions, including condyloma, lichen planus, hidradenitis suppurativa, Crohn ’s disease, lichen sclerosis and immunosuppression of various etiologies. Even when lesions are detected early, surgical excision can be difficult due to the close proximity of other vital structures, and challenges with primary closure due to the paucity of excess tissue.
A 33-year-old man with a history of Crohn ’s disease and previous bowel surgery was referred to the dermatology clinic with a 6-month history of fatigue and 3-month history of a petechial rash of the legs associated with right leg swelling and spontaneous bruising. Examination revealed perifollicular haemorrhage with hyperkeratosis and co rkscrew hairs to the legs bilaterally. There was tense swelling of the right leg with significant ecchymosis to the right posterior thigh. On further questioning, the patient admitted to eating tuna pasta exclusively and avoided fibre as to prevent exacerbation of his symptoms of Crohn’s disease.
Case reports on folliculitis as an adverse cutaneous drug reaction (ACDR) to tumor necrosis factor (TNF)-alpha inhibitors are sparse in the literature, and resolution with topical therapy has been reported. We here report 2 cases of ACDR to infliximab presenting as folliculitis, one of which required systemic therapies and the discontinuation of TNF-alpha inhibitor. Case 1: A 29-year-old male with Crohn ’s disease (CD) treated with infliximab for 7 years, in full remission, presented for evaluation of high fever, erythema with central blistering on the trunk, and pustules scattered on the whole body.
We previously published a genome-wide association study (GWAS) and meta-analysis to search for common alleles that contribute to risk of AA, and identified several genomic regions harboring potential susceptibility genes. One candidate susceptibility gene expressed in the hair follicle (HF) in AA is peroxiredoxin 5 (PRDX5) (p= of 8.7*10-14), which is also a GWAS gene in Crohn ’s disease, sarcoidosis, and psoriasis. PRDX5 is a member of the family of antioxidant enzymes that are crucial for regulating oxidative stress.