Grading immunohistochemical markers p16INK4a and HPV E4 identifies productive and transforming lesions caused by low- and high-risk HPV within high-grade anal squamous intraepithelial lesions.

CONCLUSIONS: Combined p16/E4 IHC identifies productive and non-productive HSIL associated with hrHPV within the group of HSIL defined by the Lower Anogenital Squamous Terminology recommendations. This opens the possibility of investigating selective treatment of hrHPV-caused advanced transforming HSIL and a "wait and see" policy for productive HSIL. PMID: 31302935 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31302935?dopt=Abstract

Source: The British Journal of Dermatology - July 13, 2019 Category: Dermatology Authors: Leeman A, Jenkins D, Marra E, van Zummeren M, Pirog EC, van de Sandt MM, van Eeden A, Schim van der Loeff MF, Doorbar J, de Vries HJC, van Kemenade FJ, Meijer CJLM, Quint WGV Tags: Br J Dermatol Source Type: research