Short-term Physiologic Consequences of Regional Pulmonary Vascular Occlusion in Pigs

Editor ’s PerspectiveWhat We Already Know about This TopicAfter pulmonary artery occlusion (mimicking a pulmonary embolism), perfusion is redistributed to the rest of the lung tissue, but the distribution of ventilation is uncertain.What This Article Tells Us That Is NewData from anesthetized pigs (uninjured lungs) indicate that the perfusion is redistributed as suspected. Similarly, ventilation is redistributed from nonperfused to perfused lung tissue. This limits the increase in dead space and is accompanied by less density in the occluded lung.Background Acute unilateral pulmonary arterial occlusion causes ventilation –perfusion mismatch of the affected lung area. A diversion of ventilation from nonperfused to perfused lung areas, limiting the increase in dead space, has been described. The hypothesis was that the occlusion of a distal branch of the pulmonary artery would cause local redistribution of ventilati on and changes in regional lung densitometry as assessed with quantitative computed tomography.Methods In eight healthy, anesthetized pigs (18.5 ± 3.8 kg) ventilated with constant ventilatory settings, respiratory mechanics, arterial blood gases, and quantitative computed tomography scans were recorded at baseline and 30 min after the inflation of the balloon of a pulmonary artery catheter. Regional (leftvs. right lung and perfusedvs. nonperfused area) quantitative computed tomography was performed.Results The balloon always occluded a branch of t...
Source: Anesthesiology - Category: Anesthesiology Source Type: research

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