Single dose v two-dose antenatal anti-D prophylaxis: a randomised controlled trial.

Single dose v two-dose antenatal anti-D prophylaxis: a randomised controlled trial. Med J Aust. 2019 Jul 14;: Authors: White SW, Cheng JC, Penova-Veselinovic B, Wang C, White M, Ingleby B, Arnold C, Pennell CE Abstract OBJECTIVE: To compare rates of detectability of circulating Rh(D)-immunoglobulin (anti-D) at delivery with single and two-dose antenatal anti-D prophylaxis (RAADP) regimens; to compare compliance with the two regimens. DESIGN: Open label, randomised controlled trial between May 2013 and November 2015. SETTING, PARTICIPANTS: 277 women who attended a tertiary obstetric referral hospital in Perth for antenatal care and were at least 18 years of age, less than 30 weeks pregnant and yet to receive RAADP, Rh(D)-negative (negative antibody screen), and who intended to deliver their baby at the hospital. Exclusion criteria were prior anti-D sensitisation, any contraindication of anti-D administration, and a history of isolated IgA deficiency. INTERVENTIONS: One 1500 IU anti-D dose at 28 weeks of pregnancy (single dose regimen); two doses of 625 IU each at 28 and 34 weeks of pregnancy (two-dose regimen). MAIN OUTCOME MEASURES: The primary outcome was the proportion of women with detectable anti-D levels at delivery; the secondary outcome was compliance with the allocated RAADP regimen. RESULTS: Circulating anti-D was detectable at delivery in a greater proportion of women in the two-dose group (111 of 129, 86%) than in ...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research

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In an ideal world, all IVF clinics would be equally good. They would have high quality control standards; they would be open and transparent; and would share information proactively and routinely with all their patients .This way, whether or not patients got pregnant, they would have peace of mind that they received good quality treatment.Tragically, this just does not happen in India today , and sadly the government hasn't done a good job with regulating IVF clinics, which means the quality can be extremely patchy. This means that while we do have some world class clinics, we have some terrible ones as well, which take th...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
ConclusionHysteroscopic removal of RPOC seems to have no detrimental effect on reproductive outcome and no significant effect on pregnancy rate.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionOverall, the number of complaints was significantly reduced. Only in the case of persisting adenomyosis patients suffered from ongoing postoperative complaints, as in reproductive aged women keeping the uterus was highly required. Although this pilot study about systematic posterior peritonectomy showed improved recurrence rate and fertility rate, the main question remains: does this surgical technique appropriate better results and outcomes in the future. This question has to be addressed in a prospective randomized study.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusions: Our results suggest that the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms may contribute to the susceptibility of RPL. The IL-18 -607 C > A polymorphism does not appear to influence the development of RPL. PMID: 31437073 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Authors: Sert UY, Ozel S, Neselioglu S, Erel O, Engin Ustun Y Abstract Objective: The study aims to investigate maternal serum thiol/disulfide homeostasis and ischemia-modified albumin (IMA) levels of women who were submerged during labor. Material and methods: Sixty-four pregnant women were enrolled in this study. Thirty-four women were submerged during the first stage of labor and 30 women were not. Native thiol, total thiol, disulfide, albumin, IMA, disulfide/native thiol, disulfide/total thiol and native thiol/total thiol concentrations were measured and demographic data were obtained. Results: Cord blood pH, s...
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Reproductive coercion is a form of abuse in which a girl or woman is pressured into pregnancy. From a male partner threatening to leave if his female partner refuses to have his baby, to poking holes in condoms before sex, the coercion can take shape in a variety of ways.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Publication date: Available online 22 August 2019Source: Diagnostic and Interventional ImagingAuthor(s): N. Mottet, C. Cochet, C. Vidal, J.P. Metz, S. Aubry, A. Bourtembourg, A. Eckman-Lacroix, D. Riethmuller, L. Pazart, R. RamanahAbstractPurposeThe first aim was to evaluate feasibility and reproducibility of 2-dimensional ultrasound (2D) shear wave elastography (SWE) of human fetal lungs and liver between 24 and 34 weeks of gestation. The second aim was to model fetal lung-to-liver elastography ratio (LLE ratio) and to assess its variations according to gestational age and maternal administration of corticosteroids.M...
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
AbstractMuch of the literature on the healthy worker effect focuses on studies of chronic disease and mortality; however, when studying pregnancy outcomes, these effects might differ because of the short, defined risk periods of most pregnancy outcomes. Three pregnancy-specific healthy worker effects have also been described, but the structure of these effects has not yet been investigated when occupational exposure, and not employment status, is the exposure of interest. We used directed acyclic graphs to examine healthy worker effects in studies of occupational exposures and pregnancy outcomes: the healthy hire effect, t...
Source: American Journal of Epidemiology - Category: Epidemiology Source Type: research
AbstractThe time between arrest of pregnancy development and miscarriage represents a window in which the pregnancy is nonviable and not developing. In effect, the pregnancy loss has already occurred, and additional exposure cannot influence its outcome. However, epidemiologic studies of miscarriage traditionally use gestational age at miscarriage (GAM) to assign time in survival analyses, which overestimates duration of exposure and time at risk. In Right From the Start, a pregnancy cohort study (2000 –2012), we characterized the gap between estimated gestational age at arrest of development (GAAD) and miscarriage u...
Source: American Journal of Epidemiology - Category: Epidemiology Source Type: research
Conclusions: KCl injection under ultrasonographic guidance could be a safer and more effective treatment option than surgical treatment in hemodynamically stable patients with fetal cardiac activity in interstitial pregnancy. Expectant management could be an option for patients with no fetal cardiac activity. PMID: 31432733 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
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