De novo design of symmetric ferredoxins that shuttle electrons in vivo [Biochemistry]

A symmetric origin for bacterial ferredoxins was first proposed over 50 y ago, yet, to date, no functional symmetric molecule has been constructed. It is hypothesized that extant proteins have drifted from their symmetric roots via gene duplication followed by mutations. Phylogenetic analyses of extant ferredoxins support the independent evolution...

Source: Proceedings of the National Academy of Sciences - July 15, 2019 Category: Science Authors: Andrew C. Mutter, Alexei M. Tyryshkin, Ian J. Campbell, Saroj Poudel, George N. Bennett, Jonathan J. Silberg, Vikas Nanda, Paul G. Falkowski Tags: Biological Sciences Source Type: research