Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs [Chemistry]

Tandem repeat proteins exhibit native designability and represent potentially useful scaffolds for the construction of synthetic biomimetic assemblies. We have designed 2 synthetic peptides, HEAT_R1 and LRV_M3Δ1, based on the consensus sequences of single repeats of thermophilic HEAT (PBS_HEAT) and Leucine-Rich Variant (LRV) structural motifs, respectively. Self-assembly of the peptides...

Source: Proceedings of the National Academy of Sciences - July 15, 2019 Category: Science Authors: Spencer A. Hughes, Fengbin Wang, Shengyuan Wang, Mark A. B. Kreutzberger, Tomasz Osinski, Albina Orlova, Joseph S. Wall, Xiaobing Zuo, Edward H. Egelman, Vincent P. Conticello Tags: PNAS Plus Source Type: research