Obesity Linked to Increased Risk for Pediatric Multiple Sclerosis

MONDAY, July 15, 2019 -- Obesity seems to be associated with increased odds of pediatric multiple sclerosis (MS), according to a study published online July 15 in JAMA Neurology. Brenda Huppke, M.D., from the University Medical Center G öttingen in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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ConclusionsIn Korea, the disease pattern of adult-onset MS may be changing toward a more baseline T2 MRI lesions, intrathecal B cell responses, and also higher female ratio.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Authors: Razzak HA, Harbi A, Ahli S Abstract A Depression is a prevalent mental healthcare problem and a common cause of disability worldwide. The purpose of this study was to determine the prevalence and risk factors of depression in individuals living in the UAE. We used a systematic review approach, searching PubMed and Scopus electronic databases to collect studies conducted between 2007 and 2017 on the UAE population (both citizens and expatriates) relating to depression. After evaluating and screening relevant articles, a review of 14 articles was conducted. The prevalence of depression and study populations ...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Obese children may be twice as likely to develop multiple sclerosis, a new study suggests.
Source: WebMD Health - Category: Consumer Health News Source Type: news
This study examines whether high body mass index in children and adolescents is a factor in the onset of multiple sclerosis and in treatment response.
Source: JAMA Neurology - Category: Neurology Source Type: research
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductas...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
I just cannot understand why it is so difficult to get people to grasp what seems to me a simple idea. Let's try one more time.The purpose of insurance is to spread risk. That's the essence of the concept. Health insurance (or health care insurance as some prefer to say) is different from other kinds of insurance in some ways, so let's just talk about health insurance.Health care costs are unpredictable. It is true that there are risk factors associated with some conditions, most notably smoking tobacco. Nevertheless, no matter how healthful your lifestyle, you still just might need expensive health care. You might be hit ...
Source: Stayin' Alive - Category: American Health Source Type: blogs
WEDNESDAY, June 12, 2019 -- Obesity can worsen multiple sclerosis symptoms, researchers say. Their study involved 140 patients with the relapsing-remitting form of MS, which means patients have periods of attacks (relapses), followed by periods of...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
This article summarizes recent advances in the identification of genetic and environmental factors that affect the risk of developing multiple sclerosis (MS) and the pathogenic processes involved in acute relapses and relapse-independent disability progression. RECENT FINDINGS The number of single-nucleotide polymorphisms associated with increased risk of MS has increased to more than 200 variants. The evidence for the association of Epstein-Barr virus infection, vitamin D deficiency, obesity, and smoking with increased risk of MS has further accumulated, and, in cases of obesity and vitamin D deficiency, the evidence f...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
CONCLUSION: In this series, increased BMI was associated with higher OAB and SUI USP questionnaire scores, in women presenting with MS. LEVEL OF EVIDENCE: 4. PMID: 31133495 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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