Protective role of (Bronco-T) against formaldehyde induced antioxidant, oxidative and histopathological changes in Lung of male Wistar rats

Publication date: Available online 12 July 2019Source: Toxicology ReportsAuthor(s): Sholapuri Payani, Cherlopalli Mamatha, Chinta Chandraprakash, Matcha BhaskarAbstractThe present study was sought to evaluate the oxidative, antioxidant disturbances and histopathological changes by the acute chronic exposure of formaldehyde. Bronco-T a poly-herbal formulation treatment, changes the oxidative, antioxidant status and histopathology of rat lungs with antioxidant and regenerative property. In this experiment thirty adult male albino Wister rats were used for the study and subdivided in to five groups consist of 6 rats for each group. Group-I served as control group and the other 4 groups such as II, III, IV and V are considered as experimental groups. The control and treatment rats will be maintained for 21 days of experimental period. Experimental rats are exposed to 40 percent formaldehyde for 1 hour then after one hour we treated the rats with Bronco-T and salbutamol. In the present investigation, in the rats which are inhalation of formaldehyde a series of free radical chain reactions were grimly provoked, the evaluations of antioxidant enzymes like SOD, CAT, ALT, ALAT and oxidative enzymes G-6-PDH, SDH and LDH were measured. There is a clear assertive imbalance between oxidation and anti-oxidation status was critically observed, and oxidative stress was clearly exacerbated in lung tissue by architecture of lung histopathology. Oral gavage Bronco-T exhibits a beneficial acti...
Source: Toxicology Reports - Category: Toxicology Source Type: research