Myeloid-Derived Suppressor Cells Mediate Immunosuppression After Cardiopulmonary Bypass

Conclusions: Cardiopulmonary bypass strongly impairs the adaptive immune system by triggering the accumulation of myeloid-derived suppressor cells. These myeloid-derived suppressor cells induce an immunosuppressive T cell phenotype by increasing serum arginine breakdown. Supplementation with L-arginine may be an effective measure to counteract the onset of immunoparalysis in the setting of cardiopulmonary bypass.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research