Oral geranylgeranylacetone treatment increases heat shock protein expression in human atrial tissue

Heat shock proteins (HSPs) are important chaperones which regulate the maintenance of a healthy protein quality control in the cell. Impairment of HSPs is associated with ageing-related neurodegenerative and cardiac diseases. A well-known compound to increase HSPs, through the activation of heat shock factor-1 (HSF1), is geranylgeranylacetone (GGA). GGA increases HSPs in various tissues, but so far, it is unknown whether GGA can increase HSP expression in human heart tissue.

Source: Heart Rhythm - July 11, 2019 Category: Cardiology Authors: Denise M.S van Marion, Larissa Dorsch, Femke Hoogstra-Berends, Tea Kakuchaya, Leo Bockeria, Natasja M.S de Groot, Bianca J.J.M Brundel Source Type: research