Bystander Selection for Antimicrobial Resistance: Implications for Patient Health.

Bystander Selection for Antimicrobial Resistance: Implications for Patient Health. Trends Microbiol. 2019 Jul 06;: Authors: Morley VJ, Woods RJ, Read AF Abstract Antimicrobial therapy promotes resistance emergence in target infections and in off-target microbiota. Off-target resistance emergence threatens patient health when off-target populations are a source of future infections, as they are for many important drug-resistant pathogens. However, the health risks of antimicrobial exposure in off-target populations remain largely unquantified, making rational antibiotic stewardship challenging. Here, we discuss the contribution of bystander antimicrobial exposure to the resistance crisis, the implications for antimicrobial stewardship, and some novel opportunities to limit resistance evolution while treating target pathogens. PMID: 31288975 [PubMed - as supplied by publisher]
Source: Trends in Microbiology - Category: Microbiology Authors: Tags: Trends Microbiol Source Type: research