Ultrasonic Vocalization Sex Differences in 5-HT1A-R Deficient Mouse Pups: Predictive Phenotypes Associated with Later-life Anxiety-like Behaviors.

Ultrasonic Vocalization Sex Differences in 5-HT1A-R Deficient Mouse Pups: Predictive Phenotypes Associated with Later-life Anxiety-like Behaviors. Behav Brain Res. 2019 Jul 06;:112062 Authors: Budylin T, Guariglia SR, Duran LI, Behring BM, Shaikh Z, Neuwirth LS, Banerjee P Abstract Anxiety disorders affect nearly twice as many women as men. However, little is known regarding sex-dependent developmental behavioral differences and whether there is an association with later life anxiety disorders. The present study assessed the developmental-behavioral milestones (DBMs) and their relationship with later life anxiety-like behaviors by comparing postnatal ultrasonic vocalizations (USVs) with open field (OF), elevated plus maze (EPM), and light/dark (LD) anxiety test outcomes using the serotonin 1A receptor knockout (KO) mouse model of anxiety. The USVs and DBMs (i.e., grasping, righting, and startle reflexes) were examined on postnatal day 6 (P6), P8, and P10. Adult anxiety-like behaviors were examined on P60 to compare the genotype and sex-dependent differences in anxiety-like behaviors and to correlate them with the USVs. The total number of USVs observed on P8 correlated with later life anxiety-like behaviors in a genotype-, age-, and sex-dependent manner. Interestingly, female KO (KOF) mice exhibited elevated levels of anxiety-like behavior within the OF, EPM, and LD tests. Additionally, an investigation of the USV subtypes, as well as USV sequence struct...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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Hi guys, I've been dealing with a lot lately, trying to get myself calmed down before college starts back up in a week (Senior I). I may take a few days just to compose myself before sprinting into worrying about yet another standardized test (which have been an nemesis of mine in the past). I'm having severe pre-mcat anxiety. I don't even know where to begin. My general chemistry courses and microbiology course will be this semester, which ends in December. My genetics and... The MCAT: Where TF do I start?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: MCAT: Medical College Admissions Test Source Type: forums
We examined several parameters including reproductive performance of dams, physical development, postnatal reflex ontogeny, locomotor behavior, neuromuscular strength, anxiety, anhedonic behavior, cognitive abilities and microglia populations in the F1 progeny. The study showed improved reproductive performance of Spirulina supplemented protein malnourished dams, accelerated acquisition of neurological reflexes, better physical appearance, enhanced neuromuscular strength, improved spatial learning and memory and partly normalized PMN induced hyperactivity, anxiolytic and anhedonic behavior in offspring. These beneficial ef...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
The objective of this study was to develop virtual environments that include elements that are culturally relevant to the population of the Dominican Republic. Three hundred people with symptoms of agoraphobia were interviewed. Based on the information obtained, four scenarios were designed: house, elevator, park and public transport. In each scenario, the parameters that increase anxiety levels (for example, number of people) may be controlled and modified, allowing the development of exposure levels.
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
In conclusion, most drugs are more effective than placebo, and there are few significant differences between the active drugs and placebo on acceptability. Overall, duloxetine and escitalopram showed better efficacy while vortioxetine showed better acceptability.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 16 August 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Morales-Mulia MarcelaAbstractAlcohol use is frequently associated with mood disorders. Similarly, individuals suffering from these disorders have a higher risk of developing alcoholism. Several reports have implicated orexin signaling in different behaviors related to alcohol consumption, whereas antagonists block these actions. However, the involvement of orexin-1-receptor (Orx1R) in ethanol-induced anxiolysis remains relatively unexplored. The purpose of this study was to investigate whether intra-accumbal inhibition...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: Available online 16 August 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Muhammet Serhat Özaslan, Neslihan Balcı, Yeliz Demir, Mahmut Gürbüz, Ömer İrfan KüfrevioğluAbstractThe glucose metabolism in the pentose cycle is essential to the source of NADPH. Deficiency of these enzymes have been linked to depression and psychotic disorders. Depression is an increasingly prevalent mental disorder which may cause loss of labor. Antidepressant drugs are commonly employed in treatments of mood disorders and anxiety treatment. The purpose of this study is to investigate ...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
The test could make it easier to detect autism in young children. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Autism subscribers-only Source Type: blogs
Around one-third of people over 65 are overweight or obese. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Weight Loss Source Type: blogs
The food contains a healthy fibre that reduces the risk of heart disease and stroke. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Cholesterol Source Type: blogs
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
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