Subject-Specific Studies of CSF Bulk Flow Patterns in the Spinal Canal: Implications for the Dispersion of Solute Particles in Intrathecal Drug Delivery [FUNCTIONAL]

CONCLUSIONS:
Lordosis, kyphosis, and spinal cord eccentricity in the healthy human spine result in subject-specific patterns of bulk flow recirculating regions. The extent of the interconnectivity of the streamlines among these recirculating regions is fundamental in determining the long-term transport of solute particles along the spinal canal.

Source: American Journal of Neuroradiology - July 7, 2019 Category: Radiology Authors: Coenen, W., Gutierrez-Montes, C., Sincomb, S., Criado-Hidalgo, E., Wei, K., King, K., Haughton, V., Martinez-Bazan, C., Sanchez, A. L., Lasheras, J. C. Tags: FUNCTIONAL Source Type: research