Intra-Cellular drug fails bipolar depression study; shares fall 14%

Intra-Cellular Therapies Inc said on Monday its lead drug failed to meet the main goal of a late-stage study in patients with major depressive episodes associated with bipolar disorder.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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WILMINGTON, Del., Oct. 23, 2019 -- (Healthcare Sales &Marketing Network) -- NeuroRx, Inc (NeuroRx) announced that it has signed an agreement with GEM Global Yield LLC SCS ("GEM"), the New York based private alternative investment group to provi... Biopharmaceuticals, Venture Capital NeuroRx , suicidal bipolar depression
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
Authors: Hefzi N, Grekin J, Ahmed A Abstract A 49-year-old male with major depressive disorder well-managed with venlafaxine [serotonin and norepinephrine reuptake inhibitor (SNRI)] and no history of manic episodes developed his first manic episode following use of tramadol. Tramadol-induced mania has been described with selective serotonin reuptake inhibitors but not SNRIs. In addition, mania is not listed as a potential clinical side effect-further illustrating this relative rarity. Due to tramadol's SNRI activity, there is definitive risk for mood lability in individuals managed with tramadol and other serotoner...
Source: Journal of Opioid Management - Category: Addiction Tags: J Opioid Manag Source Type: research
CONCLUSIONS Our findings showed that about 20% of the youths had at least one mental disorder. However, this prevalence is underestimated since other relevant mental disorders were not assessed. Mental disorders were associated with higher suicide risk, especially the comorbidity between them.
Source: Revista de Saude Publica - Category: International Medicine & Public Health Source Type: research
The risk of giving birth to a child with birth defects may be slightly higher in women with bipolar disorder who take lithium compared with those who do not take lithium, suggests ameta-analysis inAJP in Advance. However, these slight risks may be outweighed by the dangers to mother and child of relapse of illness episodes (either depressive or manic), the authors of the analysis caution.“Pregnancy should not be considered an absolute contraindication to lithium prescription, given the relatively small increase in risk for any malformation or cardiac malformations, and given that such events, fortunately, remain rare...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance bipolar disorder cardiac birth defect congenital defect lithium meta-analysis Michele Fornaro miscarriage relapse Source Type: research
Condition:   Bipolar Depression Interventions:   Drug: ILT101;   Drug: Placebos Sponsors:   Assistance Publique - Hôpitaux de Paris;   Iltoo Pharma Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
 Psychiatric medications are the religion and politics of the mental health advocacy world — don’t bring them up unless you want a fight to break out. Luckily, here at Not Crazy, we don’t shy away from confrontation.  In this episode, we cover the good, the bad, and the ugly surrounding medications. Like whether or not you should take them. We tackle side effects like feeling numb and sexual dysfunction and share our personal histories with medication therapy. Listen now! (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning wri...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antidepressant Antipsychotic General Medications Mental Health and Wellness Not Crazy Podcast Psychology Research Sexuality Stimulants Treatment Source Type: blogs
Publication date: November 2019Source: The Lancet Psychiatry, Volume 6, Issue 11Author(s): Verinder Sharma, Christine Baczynski
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Authors: Nogueira-Lima G, Boarati MA, Fu-I L Abstract PMID: 31617967 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Publication date: Available online 14 October 2019Source: Microchemical JournalAuthor(s): Nada S. Abdelwahab, Amal B. Ahmed, Mahmoud A. Omar, Sayed M. Derayea, Maha M. AbdelrahmanABSTRACTNewly established green TLC-densitometric and RP-HPLC methods were developed and validated for simultaneous determination of quetiapine (QUT) (an antipsychotic drug) and the co-administrated drug, paroxetine (PAR) (an antidepressant drug). Both drugs are widely prescribed for treatment of bipolar depression. The proposed TLC-densitometric method was based on separation of the studied components and the internal standard (vincamine (VINC)) ...
Source: Microchemical Journal - Category: Chemistry Source Type: research
In this report, we present a case of bipolar depression undergoing triple chronotherapy in addition to the standard treatment and discuss the importance of getting fast and sustained response in these cases. PMID: 31613981 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research
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