Ubiquitylation: How Nucleosomes Use Histones to Evict Histones.

Ubiquitylation: How Nucleosomes Use Histones to Evict Histones.
Trends Cell Biol. 2019 Jul 02;:
Authors: Krajewski WA
Abstract
Steric hindrances by bulky histone modifications (such as ubiquitylation) could destabilize and remodel canonical nucleosome structure. This highlights a novel mechanism by which bulky modifications directly regulate chromatin, distinct from the more generally accepted roles of histone modifications in the recruitment of downstream effectors and histone charge shielding.
PMID: 31277892 [PubMed - as supplied by publisher]

Source: Trends in Cell Biology - July 1, 2019 Category: Cytology Authors: Krajewski WA Tags: Trends Cell Biol Source Type: research