Circulating visfatin levels in the second and third trimester of pregnancies with gestational diabetes: a systematic review.

CONCLUSIONS: No significant difference in circulating visfatin levels in GDM during the second trimester of pregnancy (WMD -0.30 ng/mL, 95% CI: -2.06, 1.45, SE=0.895, P=0.733) was detected. Meta-analysis of the studies in the third trimester revealed a significant negative effect, that was however driven by only one study. This finding limits the meaningful interpretation of the pooled analysis. Significant heterogeneity was identified between studies, and meta-regression analysis showed that homeostatic model assessment for insulin resistance contributes significantly to heterogeneity. In conclusion, our findings suggest that peripheral blood visfatin concentration cannot be robustly associated with gestational diabetes status in the second and third trimesters of pregnancy. PMID: 31274262 [PubMed - in process]
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research