ANKRD26-RET - A novel gene fusion involving RET in papillary thyroid carcinoma

Since the 1990s, rearrangements of the RET gene were discovered as molecular alterations responsible for tumorigenesis in different cancer types. In approximately one third of papillary thyroid carcinoma cases, RET rearrangements are detectable, with a variation depending on geographical background and the applied method of assessment [1 –4]. In 1-2% of non-small cell lung cancer, RET rearrangements are detected [5]. Moreover, RET rearrangements were reported in breast cancer, colorectal cancer and other tumor entities (Table 1).

Source: Cancer Genetics and Cytogenetics - July 4, 2019 Category: Genetics & Stem Cells Authors: Julia Isabelle Staubitz, Thomas Johannes Musholt, Arno Schad, Erik Springer, Hauke Lang, Krishnaraj Rajalingam, Wilfried Roth, Nils Hartmann Tags: Original article Source Type: research