Impact of ET-1 and sex in glomerular hyperfiltration in humanized sickle cell mice

Hyperfiltration, highly prevalent early in sickle cell disease (SCD), is in part driven by an increase in ultrafiltration coefficient (Kf). The increases in Kf may be due to enlarged filtration surface area and/or increased glomerular permeability (Palb). Previous studies have demonstrated that endothelin-1 (ET-1) contributes to Palb changes in models of diabetes and SCD.  Thus, we performed longitudinal studies of renal function to determine the relationship between ET-1 and glomerular size and Palb that may contribute to hyperfiltration in humanized sickle cell (HbSS) and control (HbAA) mice 8 to 32 weeks of age. HbSS mice were characterized by significant increases in plasma and glomerular ET-1 expression in both sexes although this increase was significantly greater in males.  HbSS glomeruli of both males and females presented with a progressive and significant increase in glomerular size, volume, and Kf.  During the onset of hyperfiltration, plasma and glomerular ET-1 expression were associated with a greater increase in glomerular size and Kf in HbSS mice, regardless of sex. The pattern of Palb augmentation during the hyperfiltration was also associated with an increase in glomerular ET-1 expression, in both male and female HbSS mice. However, the increase in Palb was significantly greater in males and delayed in time in females. Additionally, selective endothelin A (ETA) receptor antagonist prevented hyperfiltration in HbSS, regardless of sex. These resu...
Source: Clinical Science - Category: Biomedical Science Authors: Tags: PublishAheadOfPrint Source Type: research

Related Links:

This article will discuss some medical conditions that might be seen by orthodontists. Also, recommendations and modifications of the orthodontic treatment plan will be discussed thoroughly.Materials and methodsA computerized electronic search of the literature was conducted in Google Scholar and PubMed and was limited to publications in English.ResultsOrthodontic management was studied in cases of Infective endocarditis (IE), Thrombocytopenia, Hemophilia, Sickle cell anemia, Thalassemia, Diabetes mellitus (DM), Thyroid Disorders, Asthma, DiGeorge Syndrome, HIV/AIDS, Organ transplantation, Orthodontic management, Juvenile ...
Source: International Orthodontics - Category: Dentistry Source Type: research
ConclusionsThe Family Relationships 8-item short form demonstrated adequate reliability and convergent/discriminant validity for use in pediatric chronic conditions, though scores above the mean displayed greater uncertainty. Evidence of the measure ’s reliability and validity in multiple contexts furthers the case for its use.
Source: Quality of Life Research - Category: Health Management Source Type: research
Abstract Soluble guanylate cyclase (sGC) is the intracellular receptor of messenger nitric oxide (NO). The activation of sGC results in the conversion of guanosine triphosphate (GTP) to the secondary messenger cyclic guanosine monophosphate (cGMP). cGMP modulates a series of cascades downstream through activating a variety of effectors, such as phosphodiesterase (PDE), protein kinase G (PKG), cyclic nucleotide gated ion channels (CNG). The NO-sGC-cGMP pathway play significant roles in various physiological processes, including platelet aggregation, smooth muscle relaxation and neurotransmitter delivery. Riociguat,...
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research
ConclusionsRenal biopsies, while not commonly performed in children with SCD, were universally abnormal. Outcomes were poor in this cohort of patients despite a variety of post-biopsy interventions. Effective early intervention to prevent chronic kidney disease (CKD) is needed to reduce morbidity and mortality in children with SCD.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conclusion: In ischemic stroke or TIA patients with platelet count within normal range, platelet count may be a qualified predictor for long-term recurrent stroke, mortality, and poor functional outcome. Introduction Platelets exert a critical role in the pathogenesis of atherosclerotic complications of cardio-cerebrovascular disease, contributing to thrombus formation, and embolism (1, 2). Previous literature reported that platelets of various size and density are produced by megakaryocytes of different size and stages of maturation in different clinical conditions, suggesting various platelet patterns in differen...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 11 April 2019Source: Journal of Herbal MedicineAuthor(s): Ombeline Danton, Aimé Somboro, Baba Fofana, Drissa Diallo, Lassine Sidibé, Catherine Rubat-Coudert, Fabien Marchand, Alain Eschalier, Sylvie Ducki, Pierre ChalardAbstractPain is among the major concerns of healthcare authorities across the world. It is complicated to diagnose, manage and treat. Current western treatments are successful to some extent in relieving pain; they provide minimum improvements in terms of physical and emotional functioning and are often accompanied by side effects. Finding new solutions in pa...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
CONCLUSIONS: The high burden of IPD in at-risk groups in our population and the associated increase in morbidity and mortality underlie the need for improved preventive and therapeutic management strategies in these patients. PMID: 30909200 [PubMed - as supplied by publisher]
Source: Human Antibodies - Category: Biochemistry Tags: Hum Antibodies Source Type: research
Chronic maternal comorbidities including sickle cell disease (SCD), chronic hypertension (CHTN) and pregestational diabetes may cause vasculopathies that lead to tissue hypoxia and subsequently an increase in maternal cell necrosis which create a dilutional effect in fetal fraction on non-invasive prenatal screening (NIPS). We sought to evaluate the impact of chronic maternal comorbidities on the NIPS no-call rate. We hypothesized that chronic maternal comorbidities would increase the no-call rate for NIPS.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session V Source Type: research
AbstractBackgroundThere is little known regarding how familiar parents are with the newborn bloodspot screening (NBS) test or how well parents of a child with a screen-detected condition understand that condition initially.AimThe study aim was to examine parental NBS awareness and conditions screened.MethodsTwo studies were conducted: [1] Parents of children with cystic fibrosis (CF) detected via NBS and subsequently, diagnosed (n = 124) completed a telephone questionnaire regarding information they received at the time of NBS. [2] A cross-sectional study of women (n = 662 (58%) antenatal;n&thin...
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
ConclusionsAlthough neither T2D nor SCT alone had significant effects on blood rheology parameters or vascular function, combined T2D-SCT mice had significantly altered blood rheology and significantly impaired vascular function.
Source: Microvascular Research - Category: Biochemistry Source Type: research
More News: Biomedical Science | Diabetes | Endocrinology | Glomeruli | Science | Sickle Cell Anemia | Study