In Silico Molecular Docking, Synthesis of 4-(4-benzoylaminophenoxy) Phenol Derivatives as Androgen Receptor Antagonists.

CONCLUSION: The present approach is simple and efficient for the synthesis of BAPP derivatives and the observed IC50 values of BAPPs were in good agreement with the glide scores obtained from the molecular docking. We, further, intend to carry out in vitro and in vivo AR binding studies for the active compounds.
PMID: 31267866 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - June 30, 2019 Category: Chemistry Authors: Elancheran R, Kabilan S, Kotoky J, Ramanathan M, Bhattacharjee A Tags: Comb Chem High Throughput Screen Source Type: research