Higher health care use before a clinically isolated syndrome with or without subsequent MS

ConclusionHealth care use was higher in individuals with a CIS than without a CIS in the five years before an incident demyelinating event, regardless of whether they were subsequently diagnosed with MS. This suggests that there is a prodromal period before CIS which is not unique to MS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research