Assembly and targeting of secretins in the bacterial outer membrane.

Assembly and targeting of secretins in the bacterial outer membrane.
Int J Med Microbiol. 2019 Jun 19;:
Authors: Natarajan J, Singh N, Rapaport D
Abstract
In Gram-negative bacteria, secretion of toxins ensure the survival of the bacterium. Such toxins are secreted by sophisticated multiprotein systems. The most conserved part in some of these secretion systems are components, called secretins, which form the outer membrane ring in these systems. Recent structural studies shed some light on the oligomeric organization of secretins. However, the mechanisms by which these proteins are targeted to the outer membrane and assemble there into ring structures are still not fully understood. This review discusses the various species-specific targeting and assembly pathways that are taken by secretins in order to form their functional oligomers.
PMID: 31262642 [PubMed - as supplied by publisher]

Source: International Journal of Medical Microbiology - June 18, 2019 Category: Microbiology Authors: Natarajan J, Singh N, Rapaport D Tags: Int J Med Microbiol Source Type: research