Mediators of the Age Effect among Patients Treated with Carotid Artery Stenting: The Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) (P02.017)

CONCLUSIONS: These data suggest that a longer carotid artery lesion length is a significant contributor to the increased risk of CAS in the elderly. However, attenuation of the age effect was modest, less than a 10% change in the hazard ratios. Other potential mediators such as tortuosity and atherosclerosis of the aortic arch and great vessels were not assessed. Non-anatomic factors that are more common with advancing age such as cerebral white matter disease and subclinical dementia were also not assessed and may play a role in how elderly patients respond to ischemic insults.Disclosure: Dr. Voeks has nothing to disclose. Dr. Farb has nothing to disclose. Dr. Heck has received personal compensation for activities with Penumbra Inc as a consultant. Dr. Roubin has received royalty payments from Abbott Vascular and Cook Inc. Dr. Moore has nothing to disclose. Dr. Logan has nothing to disclose. Dr. Longbottom has nothing to disclose. Dr. Howard has received personal compensation for activities with Bayer Healthcare and Abbott. Dr. Howard has received research support from Amgen and Bayer. Dr. Brott has received personal compensation for activities with 3D Communications and Edwards Lifesciences, LLC.
Source: Neurology - Category: Neurology Authors: Tags: P02 Cerebrovascular Disease II Source Type: research