No evidence of disease activity (NEDA) in multiple sclerosis - Shifting the goal posts

Lekha PanditAnnals of Indian Academy of Neurology 2019 22(3):261-263
A combined endpoint measure to define no evidence of disease activity (NEDA) is becoming increasingly appealing in the treatment of multiple sclerosis (MS). Initial efforts using a 3 parameter NEDA monitored disease activity using clinical and MRI lesion data. Later refinements, introduced more recently, include brain atrophy measurement and cognitive function analysis in defining NEDA-4. Using these stringent criteria clearly differentiated the usefulness of different disease modifying agents (DMDs) in achieving and sustaining NEDA over time. This in turn has changed attitudes and strategies in management of MS.

Source: Annals of Indian Academy of Neurology - June 30, 2019 Category: Neurology Authors: Lekha Pandit Source Type: research