Performance of the American College of Rheumatology 2016 criteria for fibromyalgia in a referral care setting

AbstractThe American College of Rheumatology (ACR) 2016 criteria for fibromyalgia (FM) is recommended for use in primary and referral setting. However, neither the ACR 2016 nor its predecessor ACR 2010 criteria have been validated in a referral setting. We hypothesized that the presence of higher comorbidities in the referral care setting may affect the performance of the ACR 2016. All patients referred to a tertiary care hospital with widespread pain for more than 3  months were screened using (1) the ACR 2016 criteria and (2) by a blinded expert physician (using ACR 1990 criteria). Using the ACR 1990 as reference standard, the sensitivity and specificity were calculated. Also, concomitant depression (BPHQ: Brief Patient Health Questionnaire), anxiety disorder (GAD7: Generalized Anxiety Disorder-7) and alexithymia (TAS-20: Toronto Alexithymia Scale-20) were screened for using standardized instruments. Other central sensitization syndromes were also screened clinically. Of 147 patients (132 females; median age 36 [30–45] years, median symptom duration 4 [1–6] years), 112 met the ACR 1990 criteria while 93 met the ACR 2016 criteria. There was disagreement between the two criteria in 47 patients. The sensitivity and specificity of ACR 2016 were 71% and 60%, respectively. Patients diagnosed by ACR 2016 criteria alone, had higher GAD7 scores than t hose diagnosed by the ACR 1990 alone. However, BPHQ and TAS-20 did not differ between the groups. Patients...
Source: Rheumatology International - Category: Rheumatology Source Type: research

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Authors: Theodosis-Nobelos P, Filotheidou A, Triantis C Abstract The clinical role of the placebo effect is a topic of increasing interest for the scientific community. Focus is shifting from the inert role of placebos in randomized controlled trials (RCTs) to potential effects in clinical applications, since the phenomenon is thought to be inherent in routine clinical practice, affecting therapy success rates. Mediation of the mind-brain-body relationship involves both psychosocial and neurobiological factors, the interaction of which comprises the placebo mechanisms. Psychosocial factors include environmentally i...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Publication date: Available online 17 September 2020Source: Journal of Anxiety DisordersAuthor(s): Hannah E. Frank, Emily Becker-Haimes, Lara S. Rifkin, Lesley A. Norris, Thomas H. Ollendick, Thomas M. Olino, Hilary E. Kratz, Rinad S. Beidas, Philip C. Kendall
Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
Conclusions: The main effects of T. s. stejnegeri envenomation are tissue swelling, pain, and local ecchymosis. We do not recommend the use of cold packs during first aid to reduce wound pain, as this may be a risk factor for wound necrosis. In addition, patients with bulla or blister formation should be carefully examined for subsequent wound necrosis. Antiplatelet use may worsen systemic bleeding. No severe rhabdomyolysis or renal failure was observed in this large case series, we therefore considered that they were not prominent effects of T. s. stejnegeri bite.
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - Category: Tropical Medicine Source Type: research
Authors: Liao S, Zhang Z, Li G, Zhou L, Jiang J, Zhang N, Wang Y, Du Y, Wen Z Abstract Introduction. Stable angina (SA) in coronary heart disease is a common ischemic heart disease endangering the patient's quality of life and longevity. Clinical trials have demonstrated that the Chinese herbal formula Xuefu Zhuyu (XFZY) has benefits for SA patients. However, there remains a lack of high-quality evidence to support clinical decision-making. Therefore, we designed a randomized controlled trial (RCT) to evaluate the efficacy and safety of XFZY for SA. Methods and Analysis. This multicenter, double-blinded RCT will be...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Women, patients younger than 30 years have higher rates of depression
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Dermatology, Family Medicine, Gynecology, Internal Medicine, Pharmacy, Psychiatry, Institutional, Source Type: news
CONCLUSIONS If there is long-term complaint of undiagnosed limb pain, the physician should suspect osteoid osteoma. However, the selection of treatment modality should be considered according to the location of the lesion. Which management modality is superior may change depending on the location of the lesion between CT-guided radiofrequency ablation and surgical excision. Key words: osteoid osteoma, unusual locations, CT guided, radiofrequency ablation, benign bone tumor. PMID: 32940225 [PubMed - in process]
Source: Acta Orthopaedica - Category: Orthopaedics Authors: Tags: Acta Chir Orthop Traumatol Cech Source Type: research
CONCLUSIONS Results of this study revealed that the use of 20 mg/2 ml HA injection was effective in improving the WOMAC index score in patients of knee OA. Additionally, patients' quality of life as measured by SF-36 questionnaire was also significantly improved at the end of the study. None of the patient reported any of the adverse events during the study. Overall, the 20 mg/2 ml HA injection can be considered as a good treatment option for the knee OA in patients who do not respond to non-pharmacological therapy, NSAIDs or analgesics. Key words: osteoarthritis, hyaluronic acid, injection, non-operative. PMID: 32940...
Source: Acta Orthopaedica - Category: Orthopaedics Authors: Tags: Acta Chir Orthop Traumatol Cech Source Type: research
Publication date: Available online 18 September 2020Source: Physiology &BehaviorAuthor(s): Amir Hossien Mehrsafar, Miguel Angel Serrano Rosa, Ali Moghadam Zadeh, Parisa Gazerani
Source: Physiology and Behavior - Category: Physiology Source Type: research
CONCLUSIONS: Since anxiety and hyperactivity were predictors of nomophobia according to the study, adolescents with attention deficit hyperactivity disorder or anxiety disorder should be examined for nomophobia as well. Key points Nomophobia levels of internalising and externalising disordered groups did not differ. Internalising group had higher scores in two sub-dimensions of nomophobia. All anxiety and depression symptoms correlated with nomophobia. Hyperactivity and oppositional symptoms correlated with nomophobia. Total anxiety and hyperactivity were predictors of nomophobia. PMID: 32940094 [PubMed - as supplied by publisher]
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research
Authors: Yatham LN, Vieta E, McIntyre RS, Jain R, Patel M, Earley W Abstract Introduction: Bipolar disorder is a complex mood disorder characterized by a chronic and subtle course of fluctuating manic/hypomanic and depressive symptoms. Cariprazine, a dopamine D₃-preferring D₃/D₂ receptor partial agonist with serotonin 5-HT1A receptor partial agonist and serotonin 5-HT2A antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. Post hoc analyses evaluated efficacy across symptoms in bipolar depression. Methods: Pooled data were analyzed from 3 phase 2 or 3, randomized, ...
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
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