Chemical components from the twigs of Caesalpinia latisiliqua and their antiviral activity

AbstractThree new compounds, (3S)-dihydrobonducellin 8-O- β-d-glucopyranoside (1), 3 ′,5′-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs ofCaesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined by extensive spectroscopic methods, including 1D and 2D NMR. All the isolated compounds were evaluated for their antiviral activity in HRV1B-, CVB3-, and EV71-infected cells. Among the tested compounds, three flavonoids (4–6) and two stilbenes (12 and14) exhibited significant antiviral activity. This is the first phytochemical investigation ofC. latisiliqua twigs.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research