Renal Protective Effects of Alpha-Calcitonin Gene-Related Peptide in Deoxycorticosterone- Salt Hypertension.

Renal Protective Effects of Alpha-Calcitonin Gene-Related Peptide in Deoxycorticosterone- Salt Hypertension. Am J Physiol Renal Physiol. 2013 Feb 6; Authors: Li J, Carnevale KA, Dipette DJ, Supowit SC Abstract Deoxycorticosterone salt (DOC-salt) hypertension -induced renal damage is enhanced in α-CGRP KO compared to WT mice. However, since the α-CGRP KO mice have a 15-20 mmHg higher baseline mean arterial pressure (MAP) than WT mice, they also have a higher MAP than WT mice throughout the course of DOC-salt hypertension. To determine the mechanism by which the absence of α-CGRP enhances hypertension-induced renal damage, DOC-salt hypertension was induced in telemetry probe implanted α-CGRP KO and WT mice. To equalize the blood pressure (BP) to that of DOC-salt WT mice, an additional group of DOC-salt α-CGRP KO mice was given 0.025% hydralazine to drink. The DOC-salt protocol increased the final MAP in α-CGRP KO mice to 155±6 mmHg and in WT mice to 140±5 mmHg. The MAP of the hydralazine-treated DOC-salt α-CGRP KO mice was 139±6 mmHg. Urinary excretion of microalbumin and isoprostane, a marker for oxidative stress, were increased and creatinine clearance decreased in DOC-salt α-CGRP KO compared to DOC-salt WT mice. Equalization of the MAP in DOC-salt α-CGRP KO to that of DOC-salt WT mice did not significantly improve these parameters. Renal macrophage infiltration, desmin, a marker of podocyte damage, and the inflammatory cytokines T...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research