SNMMI: PET spotlights link between Down syndrome, Alzheimer's

ANAHEIM, CA - Researchers are reporting early success in adapting a new method...Read more on AuntMinnie.comRelated Reading: PiB-PET study strengthens link between amyloid, dementia High amyloid levels on PET may indicate early Alzheimer's PiB-PET could open window on common meningiomas SNMMI: PET shows tau may be Alzheimer's catalyst SNMMI: PiB-PET finds unique Down syndrome trait
Source: Headlines - Category: Radiology Source Type: news

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Researchers Detangle Protein Interaction Implicated in Down Syndrome and Alzheimer's New findings by chemists Wolfgang Peti and Rebecca Page provide a foundation to better understand and treat these neurological disorders. Brittany Uhlorn Today BIO5 InstituteNMR_room_PC Wolfgang Peti-web.jpg The powerful biomolecular NMR spectrometers at the University of Arizona have allowed scientists to gain molecular details of the interaction between RCAN1 and calcineurin, two proteins that have long been implicated in Down syndrome and Alzheimer's disease.HealthScience and TechnologyBIO5College of ScienceMedia contact...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research
This study revealed that the amyloid assembly is mediated via binding-induced conformational switching into an early partially helical amyloid-competent intermediate. Additionally, protein and inducer concentration-dependent studies indicated that at the higher protein and/or inducer concentrations, competing off-pathway intermediates dampen the amyloid assembly which implies that the stoichiometry of protein and inducer plays a key regulatory role in the amyloid nucleation and fibril elongation kinetics. PMID: 32691116 [PubMed - as supplied by publisher]
Source: European Biophysics Journal : EBJ - Category: Physics Authors: Tags: Eur Biophys J Source Type: research
This study tests the hypothesis that identifying IFN-stimulated response element (ISRE) control sites on Ch21 will mark novel candidate genes for DS/T21-related IFN hypersensitivity and neuropathology not previously reported to be associated with IFN functions. We performed whole chromosome searches of online databases. The general ISRE consensus and gamma interferon activation consensus sequences (GAS) were used for identifying IFN-stimulated response elements. Candidate genes were defined as those possessing two or more ISRE and/or GAS control sites within and/or upstream of the transcription start site. A literature sea...
Source: Autoimmune Diseases - Category: Allergy & Immunology Tags: Autoimmune Dis Source Type: research
This article provides a summary of discussions, including noting areas of emerging science and discovery, considerations for future studies, and identifying open gaps in our understanding for future focus. PMID: 32544310 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
AbstractIndividuals with Down syndrome (DS) are at high risk for developing Alzheimer ’s disease (AD) pathology and this has provided significant insights into our understanding of the genetic basis of AD. The present review summarizes recent clinical, neuropathologic, imaging, and fluid biomarker studies of AD in DS (DSAD), highlighting the striking similarities, as well as some n otable differences, between DSAD and the more common late-onset form of AD (LOAD) in the general population, as well as the much rarer, autosomal-dominant form of AD (ADAD). There has been significant progress in our understanding of the n...
Source: CNS Drugs - Category: Neurology Source Type: research
218Background: Adults with Down syndrome (DS) are predisposed to Alzheimer’s disease (AD), with most developing clinical dementia by their late 60s. While Aβ pathology has been previously characterized in this population, its relationship with neurofibrillary tau is much less well understood. Objectives: The focus of this study is to determine the associations between global Aβ and regional tau in DS, as well as assess the differences in these biomarkers between cognitively stable adults with DS (CS) and cases of cognitive impairment (MCI/AD). Methods: A total of 140 adults with DS (age = 39.3 ± 8.4 ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science - Inflammation and Dementia Source Type: research
Cortical laminar distribution of β-amyloid deposits in five neurodegenerative disorders. Folia Neuropathol. 2020;58(1):1-9 Authors: A Armstrong R Abstract Alzheimer's disease neuropathologic change (ADNC) in the form of β-amyloid (Aβ) deposits occurs not only in Alzheimer's disease (AD) and Down's syndrome (DS) but also as a 'co-pathology' in several disorders including dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and chronic traumatic encephalopathy (CTE). To determine whether cortical laminar degeneration, as measured by Aβ deposition, is similar in different...
Source: Folia Neuropathologica - Category: Pathology Authors: Tags: Folia Neuropathol Source Type: research
Purpose of review People with Down syndrome represent the world's largest population with a genetic risk for Alzheimer's disease. This review will provide a short summary of what is known and will include recent findings from the field. Recent findings There has been an increasing focus on biomarker research in this population, with a number of studies presenting findings on promising new markers – Neurofilament Light (NfL) appears to be one such promising marker that has emerged. Imaging studies have increased our knowledge on the progression of Alzheimer's disease in this population. Summary The inclusion o...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: GERIATRIC PSYCHIATRY Source Type: research
ConclusionsFurther investigations are necessary to better evaluate the potential cognitive-enhancing role of intranasal insulin in the Down syndrome IDNCT02432716.
Source: Drugs in R&D - Category: Drugs & Pharmacology Source Type: research
Abstract Individuals with Down syndrome (DS) develop Alzheimer's disease (AD)-related neuropathology, characterized by amyloid plaques with amyloid β (Aβ) and neurofibrillary tangles with tau accumulation. Peripheral inflammation and the innate immune response are elevated in DS. Triggering receptor expressed in myeloid cells 2 (TREM2) genetic variants are risk factors for AD and other neurodegenerative diseases. Soluble TREM2 (sTREM2), a soluble cleavage product of TREM2, is elevated in AD cerebrospinal fluid and positively correlates with cognitive decline. There is relatively little information about ...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
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