SNMMI: PET spotlights link between Down syndrome, Alzheimer's

ANAHEIM, CA - Researchers are reporting early success in adapting a new method...Read more on AuntMinnie.comRelated Reading: PiB-PET study strengthens link between amyloid, dementia High amyloid levels on PET may indicate early Alzheimer's PiB-PET could open window on common meningiomas SNMMI: PET shows tau may be Alzheimer's catalyst SNMMI: PiB-PET finds unique Down syndrome trait
Source: Headlines - Category: Radiology Source Type: news

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Reply to "Down Syndrome Cognitive Marker's Significance in Alzheimer's Disease and Dementia Management". Alzheimers Dement. 2019 Aug 23;: Authors: Startin CM, Hamburg S, Hithersay R, Al-Janabi T, Mok KY, Hardy J, Strydom A PMID: 31451423 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Authors: Mahla RS PMID: 31422801 [PubMed - in process]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: August 2019Source: Alzheimer's &Dementia, Volume 15, Issue 8Author(s): Ranjeet Singh Mahla
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
DISCUSSION: The German version of the CAMDEX-DS provides an internationally recognized tool for the diagnostics and monitoring of cognitive decline in Down's syndrome. Furthermore, the German version can standardize medical care of these patients. In particular it provides a means of participation in international research trials for this at risk population. PMID: 31399752 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Gerontologie und Geriatrie - Category: Geriatrics Authors: Tags: Z Gerontol Geriatr Source Type: research
We present the case of a 56-year-old man with Down syndrome and Alzheimer-like dementia with simultaneous bilateral hip fracture. A bilateral partial hip cemented arthroplasty was performed on this patient. The aim was to avoid the partial burden that could be caused by ostheosynthesis, due to the patient's lack of cooperation arising from his mental deterioration and his problems realizing everyday activities. He was able to walk unaided with complete autonomy until his death fourth years later. In our experience, one stage surgery for bilateral hip prosthesis is safe and provides good results in patients with severe ment...
Source: Anales del Sistema Sanitario de Navarra - Category: General Medicine Authors: Tags: An Sist Sanit Navar Source Type: research
Carla M. Startin1,2,3*, Bryony Lowe2,3, Sarah Hamburg1,2,3, Rosalyn Hithersay1,2,3, Andre Strydom1,2,3 and LonDownS Consortium 1Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom2Division of Psychiatry, University College London, London, United Kingdom3LonDownS Consortium, London, United Kingdom Down syndrome (DS) is associated with intellectual disability and an ultra-high risk of developing dementia. Informant ratings are invaluable to assess abilities and related changes in adults with DS, particularl...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Source: - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
er MQ Abstract There is evidence that frontal-subcortical circuits play an important role in the initial presentation of dementia in Down syndrome (DS), including changes in behavior, a decline in working memory and executive dysfunction. We evaluated 92 individuals with DS (≥30 years of age), divided into 3 groups by diagnosis-stable cognition, prodromal dementia, and Alzheimer's disease. Each individual was evaluated with an executive protocol developed for people with intellectual disabilities and was rated for behaviors related to frontal lobe dysfunction (disinhibition, executive dysfunction, and apat...
Source: Neurobiology of Aging - Category: Geriatrics Authors: Tags: Neurobiol Aging Source Type: research
A comparison of the spatial patterns of β-amyloid (Aβ) deposits in five neurodegenerative disorders. Folia Neuropathol. 2018;56(4):284-292 Authors: A Armstrong R Abstract Alzheimer's disease neuropathologic change (ADNC) in the form of -amyloid (A) deposits is important not only in the pathogenesis of Alzheimer's disease (AD) and Down's syndrome (DS) but also as a 'co-pathology' in disorders such as dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and chronic traumatic encephalopathy (CTE). To compare cortical and hippocampal degeneration in different disorder...
Source: Folia Neuropathologica - Category: Neurology Tags: Folia Neuropathol Source Type: research
Dementia in Down syndrome: unique insights for Alzheimer disease researchDementia in Down syndrome: unique insights for Alzheimer disease research, Published online: 07 February 2019; doi:10.1038/s41582-018-0132-6Alzheimer disease (AD) pathology is found in almost all adults with Down syndrome (DS), primarily owing to overexpression of APP, present on chromosome 21. Here, Lott and Head examine the commonalities and disparities between DS and AD and highlight findings in DS that can inform research into AD in the general population.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
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