Kounis Syndrome

AbstractPurpose of ReviewSevere allergic reactions, such as anaphylaxis, may trigger acute coronary events. This is known as the Kounis syndrome (KS). The aim of the article is to give an overview of the current knowledge on this syndrome.Recent FindingsAn increasing number of cases of KS are reported in the literature. The involvement of cardiac mast cells seems to be critical in its development, through the release of mediators which may trigger acute events such as coronary vasoconstriction, arteriosclerotic plaque rupture, and coronary stent thrombosis.SummaryKS is a potentially severe condition resulting from the concurrent occurrence of a systemic allergic reaction and acute coronary events. Standardized epidemiological research is needed to determine the prevalence and risk factors of KS. Studies to further define the mechanisms underlying its development and to assess management issues are warranted.
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research