Mechanistic insight into E22Q-mutation-induced antiparallel-to-parallel β-sheet transition of Aβ16-22 fibril: An all-atom simulation study

Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP02561H, PaperXuhua Li, Jiangtao Lei, Ruxi Qi, Luogang Xie, Guanghong Wei Alzheimer disease (AD) is associated with the abnormal self-assembly of amyloid- β (Aβ) peptide into toxic oligomers and fibrils. Recent experiments reported that Aβ16-22, containing the central hydrophobic core (CHC) of... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Phys. Chem. Chem. Phys. latest articles - June 25, 2019 Category: Chemistry Authors: Xuhua Li Source Type: research