The efficacy of a & ldquo;cocktail therapy & rdquo; on Parkinson & rsquo;s disease with dementia

Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

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We would like to thank dr. Wang and his colleagues for their interest in our study. While the authors address important measures to assess the validity of a meta-analysis such as heterogeneity between studies, the pooling of Parkinson's disease (PD) patients with mild cognitive impairment (PD-MCI) and patients with dementia (PDD) and the ON or OFF state during scanning, it is important to recognize the need for sufficient power when performing subgroup analyses.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
Publication date: Available online 9 July 2019Source: NeuroscienceAuthor(s): Qiang Zhang, Dennis Jung, Travis Larson, Youngcho Kim, Nandakumar S. NarayananAbstractNeurodegenerative diseases such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and Alzheimer's disease (AD) involve loss of cholinergic neurons in the basal forebrain. Here, we investigate how cholinergic dysfunction impacts the frontal cortex during interval timing, a process that can be impaired in PD and AD patients. Interval timing requires participants to estimate an interval of several seconds by making a motor response, and depends on the me...
Source: Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: Considering our previous reports about Ca2+/cAMP signalling, I herein discussed the putative contribution of Ca2+/cAMP signalling in this link (between diabetes and PD). PMID: 31291877 [PubMed - as supplied by publisher]
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Tags: Curr Diabetes Rev Source Type: research
AbstractPurpose of reviewAutonomic dysfunction is common in dementia, particularly in the Lewy body dementias. This review considers the evidence for autonomic dysfunction in dementia, common symptoms and potential management options.Recent findingsAutonomic dysfunction has been shown in Alzheimer ’s disease and Lewy body dementias. Common symptoms include orthostatic dizziness, syncope, falls, urinary tract symptoms and constipation. Non-pharmacological management of orthostatic hypotension should include bolus water drinking. Pharmacological management may include the use of midodrine or droxidopa although the latt...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
CONCLUSION: This review helps to better understand how workplaces can contribute to later life cognitive fitness, and it offers a conceptual overview for practitioners that want to create more protective working environments or improve existing ones. PMID: 31291742 [PubMed - as supplied by publisher]
Source: American Journal of Health Promotion : AJHP - Category: International Medicine & Public Health Authors: Tags: Am J Health Promot Source Type: research
Cognitive impairment can occur in the early phase of Parkinson's disease and increases the risk of developing dementia. Cognitive deficits were shown to be associated with functional alterations in the dorsolateral prefrontal cortex (DLPFC) and caudate nucleus. Two previous transcranial magnetic stimulation studies over the left DLPFC showed short-term improvement in cognitive performance and focused on specific task.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Authors: Ferini-Strambi L, Fasiello E, Sforza M, Maria S, Galbiati A Abstract Introduction: Rapid Eye Movement (REM) sleep Behavior disorder (RBD) is a REM sleep parasomnia characterized by dream enacting behaviors allowed by the loss of physiological atonia during REM sleep. This disorder is recognized as a prodromal stage of neurodegenerative disease, in particular Parkinson's Disease (PD) and Dementia with Lewy Bodies (DLB). Therefore, a timely identification of biomarkers able to predict an early conversion into neurodegeneration is of utmost importance. Areas covered: In this review, the authors provide updated e...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Cognitive impairment and dementia are common in PD; however, no stable marker of cognitive dysfunction is available. Transcranial sonography can evaluate global and focal brain atrophy and has been widely used in the differential diagnosis of parkinsonism.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Publication date: Available online 2 July 2019Source: The Lancet NeurologyAuthor(s): Johannes Levin, Sylvia Maaß, Madeleine Schuberth, Armin Giese, Wolfgang H Oertel, Werner Poewe, Claudia Trenkwalder, Gregor K Wenning, Ulrich Mansmann, Martin Südmeyer, Karla Eggert, Brit Mollenhauer, Axel Lipp, Matthias Löhle, Joseph Classen, Alexander Münchau, Jan Kassubek, Florin Gandor, Daniela Berg, Silvia Egert-SchwenderSummaryBackgroundMultiple system atrophy is a rare neurodegenerative disease characterised by aggregation of α-synuclein in oligodendrocytes and neurons. The polyphenol epigallocatechin gall...
Source: The Lancet Neurology - Category: Neurology Source Type: research
[Prion-like Propagation of Pathological α-Synuclein in Vivo]. Yakugaku Zasshi. 2019;139(7):1007-1013 Authors: Masuda-Suzukake M, Hasegawa M Abstract α-Synuclein (αS) is the major component of the filamentous inclusions that constitute the defining characteristic of neurodegenerative synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. αS is deposited in a hyperphosphorylated and ubiquitinated form with a β-sheet-rich fibrillar structure in diseased brains. In 2008, some researchers reported that embryonic neurons transpl...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
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