Vanillin-Related N-Acylhydrazones: Synthesis, Antischistosomal Properties and Target Fishing Studies.

CONCLUSION: The GPQF-407 was revealed to be a promising antischistosomal agent which, besides presenting the N-acylhydrazone privileged scaffold, also could be easily synthesized on large scales from commercially available materials.
PMID: 31223088 [PubMed - as supplied by publisher]

Source: Current Topics in Medicinal Chemistry - June 19, 2019 Category: Chemistry Authors: Moraes J, Rando DGG, da Costa MOL, Pavani TFA, Oliveira T, Santos PFD, Amorim CR, Pinto PLS, Brito MG, Silva MPN, Roquini DB Tags: Curr Top Med Chem Source Type: research